Selecting the right PC systems for laboratory cleanrooms demands a deep understanding of both rigorous environmental requirements and high-performance computing. At PSB GmbH, our decades of experience in engineering PC-based solutions for sensitive industrial and medical settings have equipped us to address these unique challenges. We recognize that cleanroom environments require specialized systems—resistant to contaminants, with robust enclosures, advanced filtering, and reliable, quiet operation. Our approach is grounded in careful analysis of customer needs, drawing on both our in-house design capabilities and our independent, manufacturer-neutral perspective. For each application, we focus on creating tailored solutions that balance durability, compliance with cleanroom standards, and flexible integration into existing infrastructures. With every project, we aim to ensure seamless operation under demanding conditions while prioritizing the long-term value and serviceability of our systems.
Why Specialized PCs Are Necessary in Laboratory Cleanrooms
Cleanrooms in laboratories demand an exceptionally controlled environment for research, pharmaceuticals, biotechnology, and semiconductor production. A regular office PC simply cannot meet those high requirements. Devices used must not only comply with strict repeatable hygiene routines but also ensure minimal emissions and effective particulates control. The use of a Reinraum PC or a PC for laboratory cleanrooms prevents contamination, protects experiments, and maintains essential cleanliness standards defined by ISO 14644-1 and GMP guidelines. Especially in areas where even the smallest particle can ruin an analysis or batch, the integration of technology that features hermetic sealing, robust stainless steel housings, and resistance to chemical cleaning agents is vital.
For example, in an environment where precise drug formulation occurs, the use of a particulate-free computer ensures that airborne contaminants are not introduced through routine IT activity. Additionally, cleanroom-specific IT allows for secure, easy-to-clean touch displays and sealed input devices, minimizing physical and microbial hazards. These specialized PCs are crucial in supporting laboratory workflows without compromising laboratory IT hygiene. More insights into the practical differences and advantages are available in our article on industrial PC solutions for medical technology.
Standards and Guidelines for IT in Cleanrooms
The operation of IT systems in cleanroom environments is stringently regulated by international standards. The core standards include the DIN EN ISO 14644-1, which clearly classifies cleanrooms by allowed particulate counts per cubic meter, and the GMP (Good Manufacturing Practice) guidelines, which are of paramount importance in pharmaceutical and biotechnological contexts.
Overview of Key Standards
- ISO 14644-1: Defines maximum airborne particle contamination levels for various cleanroom classes (e.g., ISO Class 5 to 9). These classes determine allowable particle size and counts.
- GMP: Focuses on the safe manufacture of medicinal products. For laboratory IT, adherence to “GMP Reinraum IT” includes requirements on documentation, traceability, and hygiene control.
- IP Protection (e.g., IP65): The IP65 standard designates enclosures that are dust-tight and protected against water jets, ensuring electronics are shielded from both particulate ingress and liquid exposure during cleaning.
Any selected PC must show clear certification against these standards, including proper manufacturer documentation. For a summary of industry-standard practices and trends, see our resource on industrial computers for reliable 24/7 use.
Technical Requirements for Cleanroom PCs
A cleanroom PC must be built for compliance—starting with its physical characteristics and extending to its operational resilience. Below is an overview of the essential features that distinguish a suitable PC for laboratory cleanrooms:
Table: Typical Technical Features of Cleanroom PCs
| Feature | Description / Function | Relevance |
|---|---|---|
| Stainless steel enclosure | Corrosion-resistant, easily sterilizable, non-porous | Prevents microbial growth, ensures durability |
| Rounded edges | Facilitates thorough cleaning, no dirt traps | Supports hygiene and reduces contamination risk |
| IP65 protection | Dust-tight and water-jet proof | Allows frequent and aggressive cleaning |
| Fanless cooling | Passive heat dissipation, no airflow-generated contamination | Keeps air particle-free, minimizes risk of spreading contaminants |
| Special enclosure ventilation | Prevents heat accumulation while remaining sealed | Prolongs lifespan, ensures consistent performance |
| Touch screen operation | Sealed, flat surface, glove operable | Enables contactless, efficient use |
| Lack of abrasion-prone surfaces | No paint or coatings likely to degrade | Prevents particles, ensures product longevity |
The need for fanless embedded systems is especially evident in sensitive cleanroom applications, as explained in depth in our guide Fanless Embedded System: Your Guide to Silent Reliability. Additionally, surface abrasion resistance and compatibility with aggressive disinfectants must be considered.
Examples from Practice
- In pharmaceutical production, enclosed IP65 computers are used beside production lines to monitor processes and record batch data without risk of microbial or particle contamination.
- In semiconductor labs, equipment must withstand cleanroom protocols, including regular wipe-downs with isopropanol and operation under high humidity—a demand only met by robust hardware designed for Reinraumklasse ISO 14644-1.
Installation, Operation and Maintenance
Installing and maintaining a cleanroom PC means more than just screwing it onto a workbench. From initial set-up through daily use, procedures must align with both technical specifications and hygiene protocols.
Installation Guidelines
- Position PCs away from doors, high-traffic areas, or direct airflow to prevent unintentional contamination.
- Wall or ceiling mounts and dedicated enclosures reduce risk of accidental contact or contamination.
- Ensure all cabling and I/O areas feature gasket sealing or cable glands with IP65 protection.
For a specialized look at the challenges and solutions related to installing industrial PC systems in sensitive areas, our Fanless Industrial PC Guide provides valuable details.
Operation Best Practices
- Strict observance of clothing and glove protocols when touching IT equipment.
- Routine monitoring of all device surfaces for residue or wear.
- Software settings may need to lock down unauthorized ports or functions to reduce contamination risk.
Maintenance and Cleaning
- Use only approved agents and tools for cleaning surfaces, avoiding overly abrasive pads.
- Inspections should include checking for seal wear, screen cracks, or corrosion, as these can all harbor contaminants.
- Regular reviews of device logs and hardware for abnormal function, combined with scheduled preventive maintenance, extend life and ensure continuous compliance with GMP and ISO standards.
Market Overview and Selection Criteria
The range of cleanroom PCs encompasses everything from all-in-one touch computers to modular, configurable stainless steel computers. When choosing a solution for laboratory cleanrooms, consider these check-list criteria:
- Compliance: Does the product come with certification for Reinraumklasse ISO 14644-1 and GMP?
- Material: Stainless steel (AISI 304 or 316L) and abrasion-resistant surfaces.
- Protection class: Minimum IP65, ideally higher for harsher cleaning protocols.
- Hardware design: Fanless, sealed, and with rounded corners—no exposed seams or screws.
- Operation: Touch interface with glove support, easy software updates, remote monitoring options.
- Service and support: Manufacturer’s track record in pharmaceutical, biotech, or semiconductor fields.
- Flexibility: Options for temperature, pressure, and humidity monitoring directly integrated or easily connected.
For further insights into choosing the right system for permanent usage scenarios, our guide to industrial computers for 24/7 deployment is recommended.
FAQ: Frequently Asked Questions about PCs in Laboratory Cleanrooms
What cleanroom class do laboratory PCs need to fulfill?
The required Reinraumklasse depends on your laboratory’s processes, but most pharma and biotech environments require ISO Class 6–8 as per ISO 14644-1. Always select hardware certified for at least the class designated by your cleanroom’s process requirements.
Why is stainless steel preferred for cleanroom PC housings?
Stainless steel computer enclosures are highly resistant to corrosion and chemicals, are easy to sterilize, and avoid the particulate shedding that can occur with painted or plastic surfaces. These attributes are explained in our advice on industrial cleanroom PCs.
Can cleanroom PCs operate without a fan?
Yes—fanless computers are ideal, as they eliminate the risk of particle spread and reduce maintenance needs. For an in-depth technical review, see our dedicated guide to fanless industrial PCs.
What is the significance of IP65 for laboratory IT?
IP65 protection ensures that the PC’s enclosure is dust-proof and resistant to water jets. This means devices can be regularly cleaned without worrying about water damage or particle ingress, supporting both hygiene and operational longevity.
How can I ensure the longevity of my cleanroom PC?
Implement gentle but thorough cleaning, routinely inspect for wear, and ensure regular firmware and operating system updates. Work only with vendors that provide verifiable cleanroom GMP and ISO certifications.
The selection and deployment of PCs in laboratory cleanrooms is critical for data reliability, operational stability, and compliance with stringent cleanliness regulations. Our track record in developing and manufacturing industrial hardware that endures harsh environments directly translates to added confidence for our cleanroom customers. By rigorously testing each system—including comprehensive burn-in procedures—we guarantee optimal performance and minimal risk of downtime. PSB GmbH’s experience in delivering custom solutions sets us apart, ensuring that every system is not only technically sound but also precisely tailored to project-specific requirements. We are committed to supporting our partners and clients in navigating the evolving demands of laboratory technology, confident in our ability to deliver sustainable, reliable IT infrastructure for cleanroom excellence.
